Episódio 70: COVID-19 - atualizações

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Rapha, Kaue e Fred discutem as atualizações no tratamento, diagnóstico e quadro clínico da COVID-19.  Dúvidas e comentários manda pra gente no @tadeclinicagem Ou tadeclinicagem@gmail.com Minutagem (4:00) Testes diagnósticos do COVID (4:20) PCR - swab (7:33) Quando fazer e como interpretar o resultado? (11:50) Sorologia (18:02) Teste antígeno (19:00) Tratamento do COVID (19:50) Hidroxicloroquina (24:00) Ivermectina e Anitta (26:05) Anticorpos monoclonais (27:26) Azitromicina e infecção bacteriana secundária (31:00) Ferritina / Procalcitonina (31:46) Outros cuidados do paciente ambulatorial - isolamento (34:30) Uso do PCR para sair do isolamento (36:35) Quem deve ser isolado - contactantes (38:20) Tratamento do internado: Dexametasona (43:40) Rendesivir (46:40) Anti coagulação (49:28) Imunomodulador e plasma convalescentes (50:06) Resumos das drogas do tratamento (50:33) Tratamento não farmacológico (54:30) VNI x VM (56:24) Sequelas pos covid (59:15) Sd pos UTI ( PICS) (64:00) Parosmia (66:30) Salves (67:15) Resposta do desafio da semana anterior (68:08) Desafio da semana. REFERÊNCIAS: 1- https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-informs-public-about-possible-accuracy-concerns-abbott-id-now-point (Accessed on May 19, 2020). 2- DINNES, Jacqueline et al. Rapid, point‐of‐care antigen and molecular‐based tests for diagnosis of SARS‐CoV‐2 infection. Cochrane Database of Systematic Reviews, n. 8, 2020. 3- JOUNG, Julia et al. Detection of SARS-CoV-2 with SHERLOCK one-pot testing. New England Journal of Medicine, v. 383, n. 15, p. 1492-1494, 2020. 4- GUDBJARTSSON, Daniel F. et al. Humoral immune response to SARS-CoV-2 in Iceland. New England Journal of Medicine, v. 383, n. 18, p. 1724-1734, 2020. 5- HANSON, Kimberly E. et al. Infectious Diseases Society of America Guidelines on the Diagnosis of Coronavirus Disease 2019 (COVID-19): Serologic Testing. Clinical Infectious Diseases, 2020. 6-Tweeter Eric Feigl-Ding. 7- HANSON, Kimberly E. et al. Infectious Diseases Society of America guidelines on the diagnosis of COVID-19. Clinical Infectious Diseases, 2020. 8- WATSON, Jessica; WHITING, Penny F.; BRUSH, John E. Interpreting a covid-19 test result. Bmj, v. 369, 2020. 9- DEL RIO, Carlos; COLLINS, Lauren F.; MALANI, Preeti. Long-term health consequences of COVID-19. Jama, v. 324, n. 17, p. 1723-1724, 2020. 10- https://www.idsociety.org/covid-19-real-time-learning-network/disease-manifestations--complications/post-covid-syndrome/ 11- RECOVERY Collaborative Group, Horby P, Lim WS, et al. Dexamethasone in Hospitalized Patients with Covid-19 - Preliminary Report. N Engl J Med 2020. 12- Paranjpe I, Fuster V, Lala A, et al. Association of treatment dose anticoagulation with in-hospital survival among hospitalized patients with COVID-19. Journal of the American College of Cardiology. 2020. [In Press]. 13- Spyropoulos AC, Lipardi C, Xu J, et al. Modified IMPROVE VTE Risk score and elevated D-dimer identify a high venous thromboembolism risk in acutely ill medical population for extended thromboprophylaxis. TH Open. 2020;4(1):e59-e65. 14- Horby P, Mafham M, Linsell L, et al. Effect of hydroxychloroquine in hospitalized patients with COVID-19: preliminary results from a multi-centre, randomized, controlled trial. medRxiv. 2020;Preprint. 15- Cavalcanti AB, Zampieri FG, Rosa RG, et al. Hydroxychloroquine with or without azithromycin in mild-to-moderate COVID-19. N Engl J Med. 2020. 16- Furtado RHM, Berwanger O, Fonseca HA, et al. Azithromycin in addition to standard of care versus standard of care alone in the treatment of patients admitted to the hospital with severe COVID-19 in Brazil (COALITION II): a randomised clinical trial. Lancet. 2020. Mais referências

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