Podcast - Nefrologia

Pedro Magno, Luisa Sousa e Caio Bastos falam de 4 clinicagens sobre magnésio: Como investigar hipomagnesemia? Magnésio e a relação com outros eletrólitos? Quando repor? Como repor?Minutagem:00:00 Apresentação01:47 Roteiro02:07 Investigação da hipomagnesemia11:00 Causas de hipermagnesemia12:23 Magnésio e relação com outros eletrólitos15:57 Reposição do magnésio23:39 Vias de reposição do magnésio31:25 Breve revisão das quatro clinicagens32:34 Encerramento e salvesReferências:1. Zipursky, Jonathan et al. “Proton pump inhibitors and hospitalization with hypomagnesemia: a population-based case-control study.” PLoS medicine vol. 11,9 e1001736. 30 Sep. 2014, doi:10.1371/journal.pmed.10017362. Cheungpasitporn, Wisit et al. “Hospital-Acquired Dysmagnesemia and In-Hospital Mortality.” Medical sciences (Basel, Switzerland) vol. 8,3 37. 1 Sep. 2020, doi:10.3390/medsci80300373. ISIS-4: a randomised factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulphate in 58,050 patients with suspected acute myocardial infarction. ISIS-4 (Fourth International Study of Infarct Survival) Collaborative Group. Lancet. 1995;345(8951):669-685.4. Magnesium in Coronaries (MAGIC) Trial Investigators. Early administration of intravenous magnesium to high-risk patients with acute myocardial infarction in the Magnesium in Coronaries (MAGIC) Trial: a randomised controlled trial. Lancet. 2002;360(9341):1189-1196. doi:10.1016/s0140-6736(02)11278-55. Ray S, Park KW. Movement Disorders and Other Neurologic Impairment Associated With Hypomagnesemia: A Systematic Review. Neurol Clin Pract. 2023;13(6):e200202. doi:10.1212/CPJ.00000000002002026. De las Peñas R, Escobar Y, Henao F, Blasco A, Rodríguez CA; Spanish Society for Medical Oncology. SEOM guidelines on hydroelectrolytic disorders. Clin Transl Oncol. 2014;16(12):1051-1059. doi:10.1007/s12094-014-1234-27. Spichler A, Athanazio DA, Furtado J, Seguro A, Vinetz JM. Case report: severe, symptomatic hypomagnesemia in acute leptospirosis. Am J Trop Med Hyg. 2008;79(6):915-917.8. Porath A, Mosseri M, Harman I, Ovsyshcher I, Keynan A. Dead Sea water poisoning. Ann Emerg Med. 1989;18(2):187-191. doi:10.1016/s0196-0644(89)80112-x9. Wacker WE, Parisi AF. Magnesium metabolism. N Engl J Med. 1968;278(12):658-663. doi:10.1056/NEJM196803212781205

🚨 www.tadeclinicagem.com.br/guia - Conheça o Guia TdC com 7 dias grátis 🚨João Urbano (Joca) e Tiago discutem sobre diagnóstico de tratamento de rabdomiólise. Referências:1. BOSCH, Xavier; POCH, Esteban; GRAU, Josep M. Rhabdomyolysis and acute kidney injury. New England Journal of Medicine, v. 361, n. 1, p. 62-72, 20092. CHAVEZ, Luis O. et al. Beyond muscle destruction: a systematic review of rhabdomyolysis for clinical practice. Critical care, v. 20, n. 1, p. 1-11, 20163. STAHL, Kristina; RASTELLI, Emanuele; SCHOSER, Benedikt. A systematic review on the definition of rhabdomyolysis. Journal of neurology, v. 267, p. 877-882, 20204. MCMAHON, Gearoid M.; ZENG, Xiaoxi; WAIKAR, Sushrut S. A risk prediction score for kidney failure or mortality in rhabdomyolysis. JAMA internal medicine, v. 173, n. 19, p. 1821-1827, 20135. PERAZELLA, Mark A.; ROSNER, Mitchell H. Prevention and treatment of heme pigment-induced acute kidney injury (including rhabdomyolysis)6. BHAI, Salman; DIMACHKIE, Mazen M.; SHEFNER, Jeremy M. Rhabdomyolysis: Clinical manifestations and diagnosis

🚨 www.tadeclinicagem.com.br/guia - Conheça o Guia TdC com 7 dias grátis 🚨Luisa Souza apresenta essa caso clínico para João Mendes e nosso convidado Dr. Paulo Lins! Quais as principais causas de lesão renal aguda no paciente com cirrose? Como é a abordagem da lesão renal aguda nesses pacientes? Quando pensar em síndrome hepatorrenal? Confere nesse episódio!Referencias:Nadim MK, Garcia-Tsao G. Acute Kidney Injury in Patients with Cirrhosis. N Engl J Med. 2023 Feb 23;388(8):733-745. doi: 10.1056/NEJMra2215289. PMID: 36812435.

🚨 www.tadeclinicagem.com.br/guia - Conheça o Guia TdC com 7 dias grátis 🚨Marcela Belleza e Lucas Menezes discutem como quando repor bicarbonato, como repor e os efeitos adversos da reposição. Referências:1. Samir Jaber, et al. Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit (BICAR-ICU): a multicentre, open-label, randomised controlled, phase 3 trial. The Lancet - Published:June 14, 2018DOI:https://doi.org/10.1016/S0140-6736(18)31080-82. Michael Emmett, et al. Approach to the adult with metabolic acidosis. UpToDate 2023 3. Josh Farkas - PulmCrit: pH-guided fluid resuscitation & BICAR-ICU - 2018 4. Michael Wiederkehr, et al. Bicarbonate therapy in lactic acidosis. UpToDate 2023

🚨 www.tadeclinicagem.com.br/guia - Conheça o Guia TdC com 7 dias grátis 🚨Nessa semana, João Mendes e Luisa Sousa convidam o Layon Campagnaro para falar sobre Doença Renal Crônica! Referências:1. Kidney Disease: Improving Global Outcomes (KDIGO) Diabetes Work Group. KDIGO 2022 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease. Kidney Int. 2022 Nov;102(5S):S1-S127. doi: 10.1016/j.kint.2022.06.008. PMID: 36272764.2. Kidney Disease: Improving Global Outcomes (KDIGO) Blood Pressure Work Group. KDIGO 2021 Clinical Practice Guideline for the Management of Blood Pressure in Chronic Kidney Disease. Kidney Int. 2021 Mar;99(3S):S1-S87. doi: 10.1016/j.kint.2020.11.003. PMID: 33637192.3. Chan CT, Blankestijn PJ, Dember LM, Gallieni M, Harris DCH, Lok CE, Mehrotra R, Stevens PE, Wang AY, Cheung M, Wheeler DC, Winkelmayer WC, Pollock CA; Conference Participants. Dialysis initiation, modality choice, access, and prescription: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Kidney Int. 2019 Jul;96(1):37-47. doi: 10.1016/j.kint.2019.01.017. Epub 2019 Apr 13. PMID: 30987837.

🚨 www.tadeclinicagem.com.br/guia - Conheça o Guia TdC com 7 dias grátis 🚨Episódio curtinho! Em pouco mais de 30 minutos Iago apresenta um caso de hipocalemia para Luísa e Pedro, que destrincham a abordagem desse distúrbio tão comum na prática diária. Referências 1. Gumz ML, Rabinowitz L, Wingo CS. An integrated view of potassium homeostasis. N Engl J Med. 2015;373:60-72. 2. Palmer BF. Regulation of potassium homeostasis. Clin J Am Soc Nephrol. 2015; 10: 1050-1060 3. Palmer BF, Clegg DJ. Physiology and Pathophysiology of Potassium Homeostasis: Core Curriculum 2019. Am J Kidney Dis. Novembro de 2019; 74 (5): 682-695. doi: 10.1053 / j.ajkd.2019.03.427. Epub 2019, 19 de junho. 4. VIERA, Anthony J.; WOUK, Noah. Potassium disorders: hypokalemia and hyperkalemia. American family physician, v. 92, n. 6, p. 487-495, 2015. 5. GRAMS, Morgan E.; HOENIG, Melanie P.; HOORN, Ewout J. Evaluation of hypokalemia. Jama, v. 325, n. 12, p. 1216-1217, 2021. 6. PALMER, Biff F.; CLEGG, Deborah Joy. The use of selected urine chemistries in the diagnosis of kidney disorders. Clinical Journal of the American Society of Nephrology, v. 14, n. 2, p. 306-316, 2019.